Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor.

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca(2+)-releasing messenger. Biological data suggest that its receptor has two binding sites: one high-affinity locking site and one low-affinity opening site. To directly address the presence and function of these putative binding sites, we...

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Bibliographic Details
Main Authors: Rosen, D, Lewis, A, Mizote, A, Thomas, J, Aley, P, Vasudevan, SR, Parkesh, R, Galione, A, Izumi, M, Ganesan, A, Churchill, G
Format: Journal article
Language:English
Published: 2009