Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson's disease patients

Both phase-amplitude coupling (PAC) and beta-bursts in the subthalamic nucleus have been significantly linked to symptom severity in Parkinson's disease (PD) in humans and emerged independently as competing biomarkers for closed-loop deep brain stimulation (DBS). However, the underlying nature...

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Bibliographic Details
Main Authors: Meidahl, A, Moll, C, Van Wijk, B, Gulberti, A, Tinkhauser, G, Westphal, M, Engel, A, Hamel, W, Brown, P, Sharott, A
Format: Journal article
Language:English
Published: Elsevier 2019