FORMATION OF A NOVEL BICYCLIC GAMMA-LACTAM WITH ISOPENICILLIN-N SYNTHASE

Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.

Manylion Llyfryddiaeth
Prif Awduron:	Baldwin, J, Blackburn, J, Sako, M, Schofield, C
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1989

Eitemau Tebyg

GAMMA-LACTAM FORMATION FROM TRIPEPTIDES WITH ISOPENICILLIN-N SYNTHASE
gan: Baldwin, J, et al.
Cyhoeddwyd: (1988)

EXAFS STUDIES OF ISOPENICILLIN-N SYNTHASE
gan: Randall, C, et al.
Cyhoeddwyd: (1992)

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in ß-lactam biosynthesis
gan: Rabe, P, et al.
Cyhoeddwyd: (2018)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1991)

ISOPENICILLIN-N SYNTHASE - A NEW MODE OF REACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1992)

ENZYMATIC-SYNTHESIS OF BICYCLIC GAMMA-LACTAMS USING CLAVAMINIC ACID SYNTHASE
gan: Baldwin, J, et al.
Cyhoeddwyd: (1992)

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
gan: Roach, P, et al.
Cyhoeddwyd: (1997)

Chemo-enzymatic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
gan: Baldwin, J, et al.
Cyhoeddwyd: (1997)

SYNTHESIS OF A NOVEL BICYCLIC GAMMA-LACTAM ANALOG OF THE 1-OXAPENAMS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
gan: Baldwin, J, et al.
Cyhoeddwyd: (1992)

SYNTHESIS OF A BICYCLIC GAMMA-LACTAM DIPEPTIDE ANALOG
gan: Baldwin, J, et al.
Cyhoeddwyd: (1993)

Glutamine-330 is not essential for activity in isopenicillin N synthase from Aspergillus nidulans.
gan: Sami, M, et al.
Cyhoeddwyd: (1997)

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.
gan: Aplin, RT, et al.
Cyhoeddwyd: (1990)

Studies on side chain interactions during the isopenicillin N synthase catalysed biosynthesis of penicillins
gan: Cavelier, F, et al.
Cyhoeddwyd: (1997)

Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay.
gan: Dubus, A, et al.
Cyhoeddwyd: (2000)

Mechanistic studies on isopenicillin n synthase
gan: Abbott, S
Cyhoeddwyd: (1991)

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans.
gan: Roach, P, et al.
Cyhoeddwyd: (1995)

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue.
gan: Daruzzaman, A, et al.
Cyhoeddwyd: (2013)

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
gan: Roach, P, et al.
Cyhoeddwyd: (1995)

Crystallization and preliminary X-ray diffraction studies on a recombinant isopenicillin N synthase from Cephalosporium acremonium.
gan: Fujishima, Y, et al.
Cyhoeddwyd: (1994)

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes.
gan: Randall, C, et al.
Cyhoeddwyd: (1993)

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.
gan: Roach, P, et al.
Cyhoeddwyd: (1996)

Modification of iron binding ligands in isopenicillin n synthase
gan: Sami, M, et al.
Cyhoeddwyd: (1998)

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase.
gan: Ge, W, et al.
Cyhoeddwyd: (2010)

Photoaffinity labelling of isopenicillin N synthetase.
gan: Baldwin, J, et al.
Cyhoeddwyd: (1990)

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase.
gan: Ge, W, et al.
Cyhoeddwyd: (2010)

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue.
gan: Ge, W, et al.
Cyhoeddwyd: (2009)

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate.
gan: Long, A, et al.
Cyhoeddwyd: (2003)

Anaerobic crystallisation of an isopenicillin N synthase center dot Fe(II)center dot substrate complex demonstrated by X-ray studies
gan: Roach, P, et al.
Cyhoeddwyd: (1996)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1985)

GAMMA-LACTAM ANALOGS OF CARBAPENICILLANIC ACIDS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1986)

Photoaffinity labelling of isopenicillin N synthetase by laser-flash photolysis.
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)

THE SYNTHESIS OF POTENTIAL GAMMA-LACTAM ANTIBIOTICS CONTAINING A CYCLOSERINE NUCLEUS
gan: Baldwin, J, et al.
Cyhoeddwyd: (1990)

A GAMMA-LACTAM ANALOG OF PENEMS POSSESSING ANTIBACTERIAL ACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1986)

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron.
gan: Clifton, I, et al.
Cyhoeddwyd: (2011)

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.
gan: Aplin, RT, et al.
Cyhoeddwyd: (1993)

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
gan: Rabe, P, et al.
Cyhoeddwyd: (2022)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine.
gan: Long, A, et al.
Cyhoeddwyd: (2005)

On the diastereoselectivity of alkylations of bicyclic lactams
gan: Bailey, J, et al.
Cyhoeddwyd: (2000)

A GAMMA-LACTAM ANALOG OF THE PENEMS POSSESSING ANTIBACTERIAL ACTIVITY
gan: Baldwin, J, et al.
Cyhoeddwyd: (1989)