Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.

OBJECTIVES: To investigate the genotypic and phenotypic effects of in vitro resistance selection with lamivudine and/or the second generation non-nucleoside reverse transcriptase inhibitor (NNRTI) quinoxaline HBY097 using HIV-1 isolates carrying the multi-nucleoside resistance pattern linked to the...

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Main Authors: Van Laethem, K, Witvrouw, M, Pannecouque, C, Van Remoortel, B, Schmit, J, Esnouf, R, Kleim, J, Balzarini, J, Desmyter, J, De Clercq, E, Vandamme, A
Format: Journal article
Language:English
Published: 2001