HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

<p>Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA <em>HOTAIR</em> (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyte development. We find...

Podrobná bibliografie
Hlavní autoři:	Kuo, F-C, Neville, MJ, Sabaratnam, R, Wesolowska-Andersen, A, Phillips, D, Wittemans, LBL, van Dam, AD, Loh, NY, Todorčević, M, Denton, N, Kentistou, KA, Joshi, PK, Christodoulides, C, Langenberg, C, Collas, P, Karpe, F, Pinnick, KE
Médium:	Journal article
Jazyk:	English
Vydáno:	Cell Press 2022

Podobné jednotky

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution
Autor: Feng-Chih Kuo, a další
Vydáno: (2022-07-01)

Hedgehog signalling as a determinant of human fat expansion and distribution
Autor: van Dam, AD, a další
Vydáno: (2020)

The diabetes risk gene TCF7L2 regulates human adipose progenitor cell biology
Autor: Verma, M, a další
Vydáno: (2018)

TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes
Autor: Verma, M, a další
Vydáno: (2022)

Regional fat depot masses are influenced by protein-coding gene variants
Autor: Neville, M, a další
Vydáno: (2019)

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
Autor: Loh, NY, a další
Vydáno: (2020)

Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis
Autor: Denton, N, a další
Vydáno: (2019)

A cellular model for the investigation of depot-specific human adipocyte biology
Autor: Pinnick, K, a další
Vydáno: (2017)

RSPO3 functions via LGR4 to regulate human body fat distribution by eliciting diverse biological responses in abdominal and gluteal progenitors
Autor: Loh, N, a další
Vydáno: (2016)

MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition
Autor: Hilton, C, a další
Vydáno: (2019)

Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states
Autor: Liu, J, a další
Vydáno: (2019)

Cartilage oligomeric matrix protein is differentially expressed in human subcutaneous adipose tissue and regulates adipogenesis
Autor: Denton, N, a další
Vydáno: (2018)

Regional fat depot masses are influenced by protein-coding gene variants.
Autor: Matt J Neville, a další
Vydáno: (2019-01-01)

An optimised protocol for the investigation of insulin signalling in a human cell culture model of adipogenesis
Autor: Gamwell, JM, a další
Vydáno: (2023)

Sex hormones, adiposity, and metabolic traits in men and women: a Mendelian randomisation study
Autor: Loh, NY, a další
Vydáno: (2022)

MicroRNA-196a is a potential regulator of body fat distribution in humans
Autor: Hilton, C, a další
Vydáno: (2013)

Cartilage oligomeric matrix protein is differentially expressed in human subcutaneous adipose tissue and regulates adipogenesis
Autor: Nathan Denton, a další
Vydáno: (2018-10-01)

LRP5 promotes adipose progenitor cell fitness and adipocyte insulin sensitivity
Autor: Loh, NY, a další
Vydáno: (2025)

Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis
Autor: Evdokiia Potolitsyna, a další
Vydáno: (2022-06-01)

The associations between body fat distribution and bone mineral density in the Oxford Biobank: a cross sectional study
Autor: Hilton, C, a další
Vydáno: (2021)

Telomere length and metabolic syndrome traits: a Mendelian randomisation study
Autor: Loh, NY, a další
Vydáno: (2021)

MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix compositionResearch in context
Autor: Catriona Hilton, a další
Vydáno: (2019-06-01)

DNA methylation of genes in adipose tissue
Autor: Pinnick, K, a další
Vydáno: (2011)

Genomics of adipose tissue
Autor: Pinnick, K, a další
Vydáno: (2014)

Biology of upper-body and lower-body adipose tissue-link to whole-body phenotypes.
Autor: Karpe, F, a další
Vydáno: (2015)

DNA methylation of genes in adipose tissue.
Autor: Pinnick, K, a další
Vydáno: (2011)

An optimised protocol for the investigation of insulin signalling in a human cell culture model of adipogenesis
Autor: Jonathan M. Gamwell, a další
Vydáno: (2023-12-01)

Prioritising risk factors for type 2 diabetes: causal inference through genetic approaches
Autor: Wittemans, L, a další
Vydáno: (2018)

Hotair Is Dispensible for Mouse Development.
Autor: Ana Rita Amândio, a další
Vydáno: (2016-12-01)

Chokeberry reduces inflammation in human preadipocytes
Autor: Dale C. Brunelle, a další
Vydáno: (2024-01-01)

The influence of stationary synaptic activity on the PRC
Autor: Huguet Gemma, a další
Vydáno: (2011-07-01)

Independent domains for recruitment of PRC1 and PRC2 by human XIST.
Autor: Thomas Dixon-McDougall, a další
Vydáno: (2021-03-01)

De novo annotation of lncRNA HOTAIR transcripts by long-read RNA capture-seq reveals a differentiation-driven isoform switch
Autor: Evdokiia Potolitsyna, a další
Vydáno: (2022-09-01)

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
Autor: Nellie Y. Loh, a další
Vydáno: (2020-06-01)

The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study
Autor: Vasan, SK, a další
Vydáno: (2019)

Obesity, fat distribution and risk of cancer in women and men: a Mendelian randomisation study
Autor: Loh, NY, a další
Vydáno: (2022)

Preadipocyte seeded PLGA scaffolds for adipose tissue engineering /
Autor: Patrick, C. W., Jr.

On PRC Transport Sector
Autor: Anna Borisovna Bardal
Vydáno: (2020-04-01)

Editorial - PRC no ISI
Autor: Lisiane Bizarro
Vydáno: (2008-01-01)

HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
Autor: Martin C. Abba, a další
Vydáno: (2021-11-01)