PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia.

The transcription of key metabolic regulatory enzymes in the heart is altered in the diabetic state, yet little is known of the underlying mechanisms. The aim of this study was to investigate the role of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) in modulating cardiac insulin-sens...

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Autors principals: Panagia, M, Gibbons, G, Radda, G, Clarke, K
Format: Journal article
Idioma:English
Publicat: 2005