The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation.

The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation.

Activation of the G2/M cell cycle checkpoint by DNA damage prevents cells from entering mitosis. Centrosome separation is initiated in G2 phase and completed in M phase. This critical process for cell division is targeted by G2/M checkpoint. Here we show that Plk1 signaling plays an important role i...

Descripció completa

Dades bibliogràfiques
Autors principals:	Zhang, W, Fletcher, L, Muschel, R
Format:	Journal article
Idioma:	English
Publicat:	2005

Ítems similars

Dissecting Polo kinase recruitment to the centrosome
per: Alvarez Rodrigo, I
Publicat: (2019)

Inhibition of centrosome separation after DNA damage: a role for Nek2.
per: Fletcher, L, et al.
Publicat: (2004)

The role of Polo-like kinase 2 in synaptic function and plasticity
per: Seeburg, Daniel P. (Daniel Philip)
Publicat: (2007)

The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.
per: Conduit, P, et al.
Publicat: (2014)

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
per: Yun, Sang-Moon, et al.
Publicat: (2012)

Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres
per: McKinley, Kara Lavidge, et al.
Publicat: (2017)

The spatio-temporal regulation of Polo-like kinase 1 in DNA repair
per: Legg, K
Publicat: (2019)

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification
per: Liu, Fa, et al.
Publicat: (2014)

Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors
per: Grant, Robert A., et al.
Publicat: (2020)

The centrosome and the DNA damage induced checkpoint.
per: Fletcher, L, et al.
Publicat: (2006)

Cdk1 phosphorylates Drosophila Sas-4 to recruit Polo to daughter centrioles and convert them to centrosomes
per: Raff, J, et al.
Publicat: (2016)

Centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly
per: Wong, S-S, et al.
Publicat: (2022)

Phosphorylation of BRCA2 by the Polo-like kinase Plk1 is regulated by DNA damage and mitotic progression.
per: Lee, M, et al.
Publicat: (2004)

Investigating a role for the Stress-Activaed MAP Kinase Pathway in the response to ionizing radiation.
per: Evans, J, et al.
Publicat: (2001)

Structure and regulation of the human Nek2 centrosomal kinase.
per: Rellos, P, et al.
Publicat: (2007)

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles
per: Hymel, David, et al.
Publicat: (2023)

Phase separation and the centrosome: a fait accompli?
per: Raff, J
Publicat: (2019)

Polo kinase Cdc5 is a central regulator of meiosis I
per: Attner, Michelle Andrea, et al.
Publicat: (2014)

Ionizing Radiation
per: Hill, M, et al.
Publicat: (2019)

Beginning polo /
per: 411401 Disston, Harry
Publicat: (1973)

The role and regulation of Asterless in the centrosome cycle
per: Novak, ZA
Publicat: (2014)

Imaging with ionizing radiations /
per: 182151 Kouris, Kypros, et al.
Publicat: (1982)

Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors.
per: Bernstein, N, et al.
Publicat: (2008)

LIM kinase1 regulates mitotic centrosome integrity via its activity on dynein light intermediate chains
per: Ou, Sirong, et al.
Publicat: (2018)

Preservation of food by ionizing radiation/
per: Josephson, Edward S., et al.
Publicat: (1982)

Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models
per: Kaeppler, JR, et al.
Publicat: (2022)

Studying centrosome formation and the consequences of centrosome loss in Drosophila melanogaster
per: Baumbach, J
Publicat: (2014)

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.
per: Giet, R, et al.
Publicat: (2002)

LK6, a short lived protein kinase in Drosophila that can associate with microtubules and centrosomes.
per: Kidd, D, et al.
Publicat: (1997)

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
per: Kilgas, S, et al.
Publicat: (2021)

Centrosomes: Central no more?
per: Raff, J
Publicat: (2001)

Marco Polo : the incredible voyage /
per: 325349 Brown, Robin
Publicat: (2005)

Probing the microscopic worlds by ionizing radiation
per: Saion, Elias
Publicat: (2008)

Effect of ionizing radiation on high polymers/
per: 178894 Nikitina, T. S., et al.
Publicat: (1963)

Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit
per: Rock, Jeremy Michael, et al.
Publicat: (2013)

LK6, a novel Drosophila protein kinase that is rapidly turned over and is associated with microtubules and centrosomes.
per: Kidd, D, et al.
Publicat: (1996)

Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers.
per: Al-Assar, O, et al.
Publicat: (2009)

Signaling inhibition with radiation in colorectal cancer: clinical trials.
per: Mckenna, W, et al.
Publicat: (2003)

The role of interleukin-1 receptor-associated kinases in toll-like receptor signaling pathway
per: Wang, H, et al.
Publicat: (2011)

Elucidating the pathway of centrosome formation
per: Costa Vicente, C
Publicat: (2013)