Arginine metabolism in cancer and immunity

<p>Amino acid catabolism causing nutritional stress has emerged as a key immune escape mechanism in cancer to suppress tumour-specific lymphocytes. Here, we show that Arginase-2, the enzyme that breaks down arginine, is released in the blood of acute myeloid leukaemia (AML) patients and mou...

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Bibliographic Details
Main Author: Hadjinicolaou, A
Other Authors: Cerundolo, E
Format: Thesis
Language:English
Published: 2018