An shRNA-based screen of splicing regulators identifies SFRS3 as a negative regulator of IL-1β secretion

Abstract The generation of diversity and plasticity of transcriptional programs are key components of effective vertebrate immune responses. The role of Alternative Splicing has been recognized, but it is underappreciated and poorly understood as a critical mechanism for the regulation and fine-tuni...

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Main Authors: Moura-Alves, P, Neves-Costa, A, Raquel, H, Pacheco, T, D'Almeida, B, Rodrigues, R, Cadima-Couto, I, Chora, Â, Oliveira, M, Gama-Carvalho, M, Hacohen, N, Moita, L
Format: Journal article
Language:English
Published: Public Library of Science 2011