The effects of mutational processes and selection on driver mutations across cancer types

The effects of mutational processes and selection on driver mutations across cancer types

Epidemiological evidence has long associated environmental mutagens with increased cancer risk. However, links between specific mutation-causing processes and the acquisition of individual driver mutations have remained obscure. Here we have used public cancer sequencing data from 11,336 cancers of...

書誌詳細
主要な著者:	Temko, D, Tomlinson, I, Severini, S, Schuster-Boeckler, P, Graham, T
フォーマット:	Journal article
出版事項:	Springer Nature 2018

類似資料

The effects of mutational processes and selection on driver mutations across cancer types
著者:: Daniel Temko, 等
出版事項: (2018-05-01)

Author Correction: The effects of mutational processes and selection on driver mutations across cancer types
著者:: Daniel Temko, 等
出版事項: (2020-04-01)

Mutational landscape of cancer-driver genes across human cancers
著者:: Musalula Sinkala
出版事項: (2023-08-01)

Finding driver mutations in cancer: Elucidating the role of background mutational processes.
著者:: Anna-Leigh Brown, 等
出版事項: (2019-04-01)

5-hydroxymethylcytosine marks regions with reduced mutation frequency
著者:: Schuster-Boeckler, P, 等
出版事項: (2016)

An analysis of mutational signatures of synonymous mutations across 15 cancer types
著者:: Yannan Bin, 等
出版事項: (2019-12-01)

Mutational signature distribution varies with DNA replication timing and strand asymmetry
著者:: Tomkova, M, 等
出版事項: (2018)

Significant associations between driver gene mutations and DNA methylation alterations across many cancer types.
著者:: Yun-Ching Chen, 等
出版事項: (2017-11-01)

5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA.
著者:: Tomkova, M, 等
出版事項: (2016)

SDH mutations in cancer.
著者:: Bardella, C, 等
出版事項: (2011)

SDH mutations in cancer
著者:: Bardella, C, 等
出版事項: (2011)

Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types
著者:: Runjun D. Kumar, 等
出版事項: (2017-07-01)

5-hydroxymethylcytosine marks regions with reduced mutation frequency in human DNA
著者:: Marketa Tomkova, 等
出版事項: (2016-05-01)

Mutations, evolutionary theory and cancer.
著者:: Tomlinson, I
出版事項: (1993)

Selection, the mutation rate and cancer: ensuring that the tail does not wag the dog.
著者:: Tomlinson, I, 等
出版事項: (1999)

Tissue-Predisposition to Cancer Driver Mutations
著者:: Luriano Peters, 等
出版事項: (2024-01-01)

Commonalities and differences in the mutational signature and somatic driver mutation landscape across solid and hollow viscus organs
著者:: Ng, AS, 等
出版事項: (2023)

Analysis of 7,815 cancer exomes reveals associations between mutational processes and somatic driver mutations.
著者:: Rebecca C Poulos, 等
出版事項: (2018-11-01)

The mutation rate and cancer.
著者:: Tomlinson, I, 等
出版事項: (1996)

Multiomics analysis of tumor mutational burden across cancer types
著者:: Lin Li, 等
出版事項: (2021-01-01)

Tug-of-war between driver and passenger mutations in cancer and other adaptive processes
著者:: McFarland, Christopher D., 等
出版事項: (2015)

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response
著者:: Temko, D, 等
出版事項: (2018)

How many mutations in a cancer?
著者:: Tomlinson, I, 等
出版事項: (2002)

Mutation profiling of cancer drivers in Brazilian colorectal cancer
著者:: Wellington dos Santos, 等
出版事項: (2019-09-01)

Replicative DNA polymerase mutations in cancer.
著者:: Heitzer, E, 等
出版事項: (2014)

Replicative DNA polymerase mutations in cancer
著者:: Heitzer, E, 等
出版事項: (2014)

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors
著者:: Michael B. Mumphrey, 等
出版事項: (2023-08-01)

Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions
著者:: John K. L. Wong, 等
出版事項: (2022-01-01)

Tissue, cell and stage specificity of (epi)mutations in cancers.
著者:: Sieber, O, 等
出版事項: (2005)

KRAS Mutation Subtypes and Their Association with Other Driver Mutations in Oncogenic Pathways
著者:: Koushik Mondal, 等
出版事項: (2024-07-01)

Driver Mutations in Lung Cancer—Mapping the Way Forward
著者:: Arun Chandrasekharan
出版事項: (2022-07-01)

Cis-regulatory mutations with driver hallmarks in major cancers
著者:: Zhongshan Cheng, 等
出版事項: (2021-03-01)

Advances on Driver Mutations of Small Cell Lung Cancer
著者:: Bing TONG, 等
出版事項: (2016-04-01)

An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer.
著者:: Jasmine Foo, 等
出版事項: (2015-09-01)

Mutations in Cancer Driver Genes: An Insight into Prostate Cancer Progression
著者:: Sahdeo, 等
出版事項: (2019-09-01)

Identification of Single Nucleotide Non-coding Driver Mutations in Cancer
著者:: Kok A. Gan, 等
出版事項: (2018-02-01)

CDMPred: a tool for predicting cancer driver missense mutations with high-quality passenger mutations
著者:: Lihua Wang, 等
出版事項: (2024-09-01)

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer
著者:: Ming-Jun Shi, 等
出版事項: (2020-09-01)

Discovering novel driver mutations from pan-cancer analysis of mutational and gene expression profiles.
著者:: Houriiyah Tegally, 等
出版事項: (2020-01-01)

Integrated analysis of the immunological and genetic status in and across cancer types: impact of mutational signatures beyond tumor mutational burden
著者:: Jan Budczies, 等
出版事項: (2018-12-01)