Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

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Covalent modifications to histones play important roles in chromatin dynamics and the regulation of gene expression. The JumonjiC (JmjC)-containing histone demethylases (HDMs) catalyze the demethylation of methylated lysine residues on histone tails. Here we report the development of homogeneous lum...

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Bibliographic Details
Main Authors: Kawamura, A, Tumber, A, Rose, N, King, O, Daniel, M, Oppermann, U, Heightman, T, Schofield, C
Format: Journal article
Language:English
Published: 2010
Subjects:
Jumonji Domain-Containing Histone Demethylases
Protein Isoforms
metabolism
Luminescent Measurements
Biocatalysis
Protein Binding
pharmacology
methods
Enzyme Inhibitors
Peptides
chemistry
Protein Structure, Tertiary

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