Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

Covalent modifications to histones play important roles in chromatin dynamics and the regulation of gene expression. The JumonjiC (JmjC)-containing histone demethylases (HDMs) catalyze the demethylation of methylated lysine residues on histone tails. Here we report the development of homogeneous lum...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Kawamura, A, Tumber, A, Rose, N, King, O, Daniel, M, Oppermann, U, Heightman, T, Schofield, C
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2010
विषय:	Jumonji Domain-Containing Histone Demethylases Protein Isoforms metabolism Luminescent Measurements Biocatalysis Protein Binding pharmacology methods Enzyme Inhibitors Peptides chemistry Protein Structure, Tertiary

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

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