The ubiquitin-proteasome pathway in cancer.
Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. R...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1826276674692448256 |
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| author | Spataro, V Norbury, C Harris, A |
| author_facet | Spataro, V Norbury, C Harris, A |
| author_sort | Spataro, V |
| collection | OXFORD |
| description | Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. Recent work, reviewed here, has shown that this pathway is often the target of cancer-related deregulation and can underlie processes, such as oncogenic transformation, tumour progression, escape from immune surveillance and drug resistance. |
| first_indexed | 2024-03-06T23:17:28Z |
| format | Journal article |
| id | oxford-uuid:679e5845-840c-4e9d-9559-e69a2c26bc76 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:17:28Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:679e5845-840c-4e9d-9559-e69a2c26bc762022-03-26T18:39:33ZThe ubiquitin-proteasome pathway in cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:679e5845-840c-4e9d-9559-e69a2c26bc76EnglishSymplectic Elements at Oxford1998Spataro, VNorbury, CHarris, ADegradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. Recent work, reviewed here, has shown that this pathway is often the target of cancer-related deregulation and can underlie processes, such as oncogenic transformation, tumour progression, escape from immune surveillance and drug resistance. |
| spellingShingle | Spataro, V Norbury, C Harris, A The ubiquitin-proteasome pathway in cancer. |
| title | The ubiquitin-proteasome pathway in cancer. |
| title_full | The ubiquitin-proteasome pathway in cancer. |
| title_fullStr | The ubiquitin-proteasome pathway in cancer. |
| title_full_unstemmed | The ubiquitin-proteasome pathway in cancer. |
| title_short | The ubiquitin-proteasome pathway in cancer. |
| title_sort | ubiquitin proteasome pathway in cancer |
| work_keys_str_mv | AT spatarov theubiquitinproteasomepathwayincancer AT norburyc theubiquitinproteasomepathwayincancer AT harrisa theubiquitinproteasomepathwayincancer AT spatarov ubiquitinproteasomepathwayincancer AT norburyc ubiquitinproteasomepathwayincancer AT harrisa ubiquitinproteasomepathwayincancer |