Inhibition of JMJD6 by 2-oxoglutarate mimics

Studies on the inhibition of the human 2-oxoglutarate dependent oxygenase JMJD6, which is a cancer target, by 2-oxoglutarate mimics / competitors, including human drugs, drug candidates, and metabolites relevant to cancer are described. JMJD6 assays employed NMR to monitor inhibitor binding and use...

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Bibliographic Details
Main Authors: Islam, MS, Thinnes, C, Holt-Martyn, J, Chowdhury, R, McDonough, M, Schofield, C
Format: Journal article
Language:English
Published: Chemistry Europe 2021