In silico guided reconstruction and analysis of ICAM-1-binding var genes from 1 Plasmodium falciparum

The Plasmodium falciparum variant surface antigen PfEMP1 expressed on the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the high degree of sequence di...

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Bibliographic Details
Main Authors: Carrington, E, Otto, T, Szestak, T, Lennartz, F, Higgins, M, Newbold, C, Craig, A
Format: Journal article
Published: Nature Publishing Group 2018