In silico guided reconstruction and analysis of ICAM-1-binding var genes from 1 Plasmodium falciparum

The Plasmodium falciparum variant surface antigen PfEMP1 expressed on the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the high degree of sequence di...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors: Carrington, E, Otto, T, Szestak, T, Lennartz, F, Higgins, M, Newbold, C, Craig, A
Format: Journal article
Udgivet: Nature Publishing Group 2018