Supramolecular iron cylinder with unprecedented DNA binding is a potent cytostatic and apoptotic agent without exhibiting genotoxicity.

Supramolecular iron cylinder with unprecedented DNA binding is a potent cytostatic and apoptotic agent without exhibiting genotoxicity.

The supramolecular iron cylinder, [Fe(2)L(3)]Cl(4) (L = C(25)H(20)N(4)), shows unprecedented DNA binding in vitro, inducing intramolecular DNA coiling and also targeting Y-shaped DNA junctions. We investigated its effects on proliferation and survival in both tumor and normal cell lines. Iron cylind...

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Bibliographic Details
Main Authors: Hotze, A, Hodges, N, Hayden, R, Sanchez-Cano, C, Paines, C, Male, N, Tse, M, Bunce, C, Chipman, J, Hannon, M
Format: Journal article
Language:English
Published: 2008

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