Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity.

GH has potent effects on adipocyte biology, stimulating lipolysis but also promoting preadipocyte proliferation. In addition, GH, acting through IGF-I, inhibits 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which converts the inactive glucocorticoid, cortisone (E), to active cortisol (...

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Bibliografische gegevens
Hoofdauteurs:	Tomlinson, J, Crabtree, N, Clark, P, Holder, G, Toogood, A, Shackleton, C, Stewart, P
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2003

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