Structural basis of haptoglobin-haemoglobin scavenging by CD163

Haemoglobin (Hb) is essential for oxygen transport in vertebrates. However, when it is released from red blood cells, its haem group becomes reactive and must be tightly regulated to prevent its toxicity. Haptoglobin (Hp) acts as the first line of defence by scavenging Hb in the serum. Humans produc...