Human AGR2 deficiency causes mucus barrier dysfunction and infantile inflammatory bowel disease

<br><strong>Background & Aims<br></strong> The gastrointestinal epithelium plays a crucial role in maintaining homeostasis with the gut microbiome. Mucins are essential for intestinal barrier function and serve as a scaffold for antimicrobial factors. Mucin 2 (MUC2) is th...

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Bibliographic Details
Main Authors: Al-Shaibi, AA, Abdel-Motal, UM, Hubrack, SZ, Bullock, AN, Al-Marri, AA, Agrebi, N, Al-Subaiey, AA, Ibrahim, NA, Charles, AK, Elawad, M, Uhlig, HH, Lo, B
Other Authors: COLORS in IBD-Qatar study group
Format: Journal article
Language:English
Published: Elsevier 2021