Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation

Protein post-translational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signalling cascade that coordinates break repair with cell cycle progression. Here, we performed whole-cell...

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Bibliographic Details
Main Authors: Halim, VA, García-Santisteban, I, Warmerdam, DO, van den Broek, B, Heck, AJR, Mohammed, S, Medema, RH
Format: Journal article
Language:English
Published: American Society for Biochemistry and Molecular Biology 2018