Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE l...

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Váldodahkkit: Orlando, IMC, Lafleur, VN, Storti, F, Spielmann, P, Crowther, L, Santambrogio, S, Schödel, J, Hoogewijs, D, Mole, DR, Wenger, RH
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: Ferrata Storti Foundation 2019