Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit.
The second messenger cyclic Adenosine MonoPosphate (cAMP) mediates many biological process by interacting with structurally conserved nucleotide binding domains (cNBD's). Here, we use molecular dynamics simulations on RIIbeta-PKA, one of the best characterized members of the cNBD family, in pre...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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