MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.

BACKGROUND: The role of circulating homocysteine as an atherosclerosis risk factor has recently been questioned. However, 5-methyl-tetrahydrofolate (5-MTHF), the circulating metabolite of folic acid participating in homocysteine metabolism, has direct effects on vascular function. We sought to dist...

詳細記述

書誌詳細
主要な著者: Antoniades, C, Shirodaria, C, Leeson, P, Baarholm, O, Van-Assche, T, Cunnington, C, Pillai, R, Ratnatunga, C, Tousoulis, D, Stefanadis, C, Refsum, H, Channon, K
フォーマット: Journal article
言語:English
出版事項: 2009