A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates a...

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Main Authors: Ried, J, Jeff M, J, Chu, A, Bragg-Gresham, J, van Dongen, J, Huffman, J, Ahluwalia, T, Cadby, G, Eklund, N, Eriksson, J, Esko, T, Feitosa, M, Goel, A, Gorski, M, Hayward, C, Heard-Costa, N, Jackson, A, Jokinen, E, Kanoni, S, Kristiansson, K, Kutalik, Z, Lahti, J, Luan, J, Mägi, R, Mahajan, A, Mangino, M, Medina-Gomez, C, Monda, K, Nolte, I, Pérusse, L, Prokopenko, I, Qi, L, Rose, L, Salvi, E, Smith, M, Snieder, H, Stančáková, A, Ju Sung, Y, Tachmazidou, I, Teumer, A, Thorleifsson, G, van der Harst, P, Walker, R, Wang, S, Wild, S, Willems, S, Wong, A, Zhang, W, Albrecht, E, Couto Alves, A, Bakker, S, Barlassina, C, Bartz, T, Beilby, J, Bellis, C, Bergman, R, Bergmann, S, Blangero, J, Blüher, M, Boerwinkle, E, Bonnycastle, L, Bornstein, S, Bruinenberg, M, Campbell, H, Chen, Y, Chiang, C, Chines, P, Collins, F, Cucca, F, Cupples, L, D'Avila, F, de Geus, E, Dedoussis, G, Dimitriou, M, Döring, A, Farmaki, A, Farrall, M, Ferreira, T, Fischer, K, Forouhi, N, Friedrich, N, Gjesing, A, Glorioso, N, Graff, M, Grallert, H, Grarup, N, Gräßler, J, Grewal, J, Hamsten, A, Harder, M, Hartman, C, Hassinen, M, Hastie, N, Hattersley, A, Havulinna, A, Heliövaara, M, Hillege, H, Hofman, A, Holmen, O, Homuth, G, Hottenga, J, Hui, J, Husemoen, L, Hysi, P, Isaacs, A, Ittermann, T, Jalilzadeh, S, James, A, Jørgensen, T, Jousilahti, P, Jula, A, Marie Justesen, J, Justice, A, Kähönen, M, Karaleftheri, M, Tee Khaw, K, Keinanen-Kiukaanniemi, S, Kinnunen, L, Knekt, P, Koistinen, H, Kolcic, I, Kooner, I, Koskinen, S, Kovacs, P, Kyriakou, T, Laitinen, T, Langenberg, C, Lewin, A, Lichtner, P, Lindgren, C, Lindström, J, Linneberg, A, Lorbeer, R, Lorentzon, M, Luben, R, Lyssenko, V, Männistö, S, Manunta, P, Leach, I, McArdle, W, Mcknight, B, Mohlke, K, Mihailov, E, Milani, L, Mills, R, Montasser, M, Morris, A, Müller, G, Musk, A, Narisu, N, Ong, K, Oostra, B, Osmond, C, Palotie, A, Pankow, J, Paternoster, L, Penninx, B, Pichler, I, Pilia, M, Polašek, O, Pramstaller, P, Raitakari, O, Rankinen, T, Rao, D, Rayner, N, Ribel-Madsen, R, Rice, T, Richards, M, Ridker, P, Rivadeneira, F, Ryan, K, Sanna, S, Sarzynski, M, Scholtens, S, Scott, R, Sebert, S, Southam, L, Sparsø, T, Steinthorsdottir, V, Stirrups, K, Stolk, R, Strauch, K, Stringham, H, Swertz, M, Swift, A, Tönjes, A, Tsafantakis, E, van der Most, P, Van Vliet-Ostaptchouk, J, Vandenput, L, Vartiainen, E, Venturini, C, Verweij, N, Viikari, J, Vitart, V, Vohl, M, Vonk, J, Waeber, G, Widén, E, Willemsen, G, Wilsgaard, T, Winkler, T, Wright, A, Yerges-Armstrong, L, Hua Zhao, J, Carola Zillikens, M, Boomsma, D, Bouchard, C, Chambers, J, Chasman, D, Cusi, D, Gansevoort, R, Gieger, C, Hansen, T, Hicks, A, Hu, F, Hveem, K, Jarvelin, M, Kajantie, E, Kooner, J, Kuh, D, Kuusisto, J, Laakso, M, Lakka, T, Lehtimäki, T, Metspalu, A, Njølstad, I, Ohlsson, C, Oldehinkel, A, Palmer, L, Pedersen, O, Perola, M, Peters, A, Psaty, B, Puolijoki, H, Rauramaa, R, Rudan, I, Salomaa, V, Schwarz, P, Shudiner, A, Smit, J, Sørensen, T, Spector, T, Stefansson, K, Stumvoll, M, Tremblay, A, Tuomilehto, J, Uitterlinden, A, Uusitupa, M, Völker, U, Vollenweider, P, Wareham, N, Watkins, H, Wilson, J, Zeggini, E, Abecasis, G, Boehnke, M, Borecki, I, Deloukas, P, van Duijn, C, Fox, C, Groop, L, Heid, I, Hunter, D, Kaplan, R, McCarthy, M, North, K, O'Connell, J, Schlessinger, D, Thorsteinsdottir, U, Strachan, D, Frayling, T, Hirschhorn, J, Müller-Nurasyid, M, Loos, R
Format: Journal article
Language:English
Published: Nature Publishing Group 2016

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