The loss of ATRX increases susceptibility to pancreatic injury and oncogenic KRAS in female but not male mice

<strong>Background</strong> Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America, accounting for &gt;30,000 deaths annually. Although somatic activating mutations in KRAS appear in 97% of PDAC patients, additional factors are required to...

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Những tác giả chính: Young, C, Baker, R, Howlett, C, Hryciw, T, Herman, J, Higgs, D, Gibbons, R, Crawford, H, Brown, A, Pin, C
Định dạng: Journal article
Được phát hành: Elsevier 2018