Overexpression of lymphotoxin in T cells induces fulminant thymic involution.

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.

Activated lymphocytes and lymphoid-tissue inducer cells express lymphotoxins (LTs), which are essential for the organogenesis and maintenance of lymphoreticular microenvironments. Here we describe that T-cell-restricted overexpression of LT induces fulminant thymic involution. This phenotype was pre...

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Bibliographic Details
Main Authors: Heikenwalder, M, Prinz, M, Zeller, N, Lang, K, Junt, T, Rossi, S, Tumanov, A, Schmidt, H, Priller, J, Flatz, L, Rülicke, T, Macpherson, A, Holländer, G, Nedospasov, SA, Aguzzi, A
Format: Journal article
Language:English
Published: 2008

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