Structure of the complex of an Fab fragment of a neutralizing antibody with foot-and-mouth disease virus: positioning of a highly mobile antigenic loop.

Data from cryo-electron microscopy and X-ray crystallography have been combined to study the interactions of foot-and-mouth disease virus serotype C (FMDV-C) with a strongly neutralizing monoclonal antibody (mAb) SD6. The mAb SD6 binds to the long flexible GH-loop of viral protein 1 (VP1) which also...

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Bibliographic Details
Main Authors: Hewat, E, Verdaguer, N, Fita, I, Blakemore, W, Brookes, S, King, A, Newman, J, Domingo, E, Mateu, MG, Stuart, D
Format: Journal article
Language:English
Published: 1997