Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

Bromodomain protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain (BET) protein family. It binds to acetylated histone tails via its tandem bromodomains BD1 and BD2 and forms a complex with the positive transcription elongation factor b, which controls phosphorylation of RNA poly...

书目详细资料
Main Authors:	Jung, M, Philpott, M, Müller, S, Schulze, J, Badock, V, Eberspächer, U, Moosmayer, D, Bader, B, Schmees, N, Fernández-Montalván, A, Haendler, B
格式:	Journal article
语言:	English
出版:	American Society for Biochemistry and Molecular Biology Inc. 2014

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