Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.
The CD200 receptor (CD200R) negatively regulates myeloid cells by interacting with its widely expressed ligand CD200. CD200R signals through a unique inhibitory pathway involving a direct interaction with the adaptor protein downstream of tyrosine kinase 2 (Dok2) and the subsequent recruitment and a...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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