Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean
Several human genetic disorders of hemoglobin have risen in frequency because of the protection they offer against death from malaria, sickle-cell anaemia being a canonical example. Here we address the issue of why this highly protective mutant, present at high frequencies in subSaharan Africa, is u...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
National Academy of Sciences of the United States
2009
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| 主题: |