Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neo-antigen burden and immune response

Genomic instability, a hallmark of cancer, is generally thought to occur in the mid to late stages of tumorigenesis, following the acquisition of permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are notable for th...

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Bibliographic Details
Main Authors: Temko, D, Van Gool, IC, Rayner, E, Glaire, M, Makino, S, Brown, MW, Chegwidden, L, Palles, C, Depreeuw, J, Beggs, A, Stathopoulou, C, Mason, J, Baker, A-M, Williams, M, Cerundolo, E, Rei, M, Taylor, J, Schuh, A, Ahmed, A, Amant, F, Lambrechts, D, Smit, VTHBM, Bosse, T, Graham, TA, Church, DN, Tomlinson, I
Format: Journal article
Published: Wiley 2018

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