Epigenetic silencing of HNF1A associates with changes in the composition of the human plasma N-glycome.

Protein glycosylation is a ubiquitous modification that affects the structure and function of proteins. Our recent genome wide association study identified transcription factor HNF1A as an important regulator of plasma protein glycosylation. To evaluate the potential impact of epigenetic regulation...

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Dades bibliogràfiques
Autors principals: Zoldoš, V, Horvat, T, Novokmet, M, Cuenin, C, Mužinić, A, Pučić, M, Huffman, J, Gornik, O, Polašek, O, Campbell, H, Hayward, C, Wright, A, Rudan, I, Owen, K, McCarthy, M, Herceg, Z, Lauc, G
Format: Journal article
Idioma:English
Publicat: 2012