Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones

Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones

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Development of resistance to endocrine therapy is a clinical issue in estrogen receptor (ER)-positive breast cancer. Here we show that persistent activation of AKT/mTOR signaling is crucial to the acquisition of letrozole resistance in cell clones generated from MCF-7/AROM-1 aromatase-expressing bre...

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Bibliographic Details
Main Authors: Cavazzoni, A, Bonelli, M, Fumarola, C, La Monica, S, Airoud, K, Bertoni, R, Alfieri, R, Galetti, M, Tramonti, S, Galvani, E, Harris, A, Martin, L, Andreis, D, Bottini, A, Generali, D, Petronini, P
Format: Journal article
Language:English
Published: 2012

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