Selective Activation of the ortho C-F Bond in Pentafluoropyridine by Zerovalent Nickel: Reaction via a Metallophosphorane Intermediate Stabilized by Neighboring Group Assistance from the Pyridyl Nitrogen
Density functional theory is used to explore the origins of the chemoselectivity and regioselectivity of activation of C?F bonds in pentafluoropyridine with [Ni(PR3)2] species. Experimentally, Ni-fluoride species are observed and activation occurs preferentially at the 2-position (i.e., the C?F bond...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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