HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

Polymorphisms in the human leukocyte antigen (HLA) genes strongly influence autoimmune disease risk. HLA risk alleles may influence thymic selection to increase the frequency of T cell receptors (TCRs) reactive to autoantigens (central hypothesis). However, research in human autoimmunity has provide...

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Bibliographic Details
Main Authors:	Ishigaki, K, Lagattuta, KA, Luo, Y, James, EA, Buckner, JH, Raychaudhuri, S
Format:	Journal article
Language:	English
Published:	Springer Nature 2022

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