Characterization of the ATP4 ion pump in Toxoplasma gondii

The Plasmodium falciparum ATPase PfATP4 is the target of a diverse range of antimalarial compounds, including the clinical drug candidate cipargamin. PfATP4 was originally annotated as a Ca2+ transporter, but recent evidence suggests that it is a Na+ efflux pump, extruding Na+ in exchange for H+....

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Bibliographic Details
Main Authors: Lehane, A, Dennis, A, Bray, K, Li, D, Rajendran, E, McCoy, J, McArthur, H, Winterberg, M, Rahimi, F, Tonkin, C, Kirk, K, Van Dooren, G
Format: Journal article
Language:English
Published: American Society for Biochemistry and Molecular Biology 2019