Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina

Although adeno-associated viral (AAV) vector-mediated retinal gene therapies have demonstrated efficacy, the mechanisms underlying dose-dependent retinal inflammation remain poorly understood. Here we present a quantitative analysis of cellular immune response to subretinal AAV gene therapy in mice...

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Detalhes bibliográficos
Principais autores: Chandler, LC, McClements, ME, Yusuf, IH, Martinez-Fernandez de la Camara, C, MacLaren, RE, Xue, K
Formato: Journal article
Idioma:English
Publicado em: Cell Press 2021