H+-activated Na+ influx in the ventricular myocyte couples Ca2+-signalling to intracellular pH
Acid extrusion on Na+-coupled pH-regulatory proteins (pH-transporters), Na+/H+ exchange (NHE1) and Na+-HCO3- co-transport (NBC), drives Na+ influx into the ventricular myocyte. This H+-activated Na+-influx is acutely up-regulated at pHi<7.2, greatly exceeding Na+-efflux on the Na+/K+ ATPase....
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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