Identification of a novel family of presenilin homologues.
Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Presenilins have been shown to influence limited proteolysis of amyloid beta protein precursor (APP), Notch and ErbB4, and have been proposed to be gamma-secretas...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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