Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was Fisher's infinitesimal model of a large number of genetic variants, each with very small effects, whose causal effects could not be individuall...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Crouch, DJM, Bodmer, WF
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	National Academy of Sciences 2020

Antzeko izenburuak

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Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing
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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
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Argitaratua: (2011)

Genomic inflation factors under polygenic inheritance.
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Genome editing, Goldilocks and polygenic risk scores
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Implementation and implications for polygenic risk scores in healthcare
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On cross-ancestry cancer polygenic risk scores.
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Polygenic risk scores: a biased prediction?
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Power and predictive accuracy of polygenic risk scores.
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Prospects for using risk scores in polygenic medicine
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Association between polygenic risk score and risk of myopia
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Polygenic risk scores and breast cancer risk prediction
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Polygenic risk scores in the clinic: Translating risk into action
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Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
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Polygenic risk and hazard scores for Alzheimer's disease prediction
nork: Leonenko, G, et al.
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Multiancestry transferability of a polygenic risk score for diverticulitis
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Pharmacogenomics polygenic risk score: Ready or not for prime time?
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Will polygenic risk scores for cancer ever be clinically useful?
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Polygenic Risk Scores for Bipolar Disorder: Progress and Perspectives
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Generalisation of genomic findings and applications of polygenic risk scores
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Transferability of polygenic risk score among diverse ancestries
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