Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants

The reconciliation between Mendelian inheritance of discrete traits and the genetically based correlation between relatives for quantitative traits was Fisher's infinitesimal model of a large number of genetic variants, each with very small effects, whose causal effects could not be individuall...

Полное описание

Библиографические подробности
Главные авторы:	Crouch, DJM, Bodmer, WF
Формат:	Journal article
Язык:	English
Опубликовано:	National Academy of Sciences 2020

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