ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis.
OBJECTIVE: To assess the therapeutic potential of anti-CD3 monoclonal antibodies (mAb) for rheumatoid arthritis, using collagen-induced arthritis as an animal model. METHODS: Arthritis was induced in DBA/1 mice by immunization with type II collagen. After disease onset, a single injection of anti-C...
Հիմնական հեղինակներ: | Notley, C, McCann, F, Inglis, J, Williams, R |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
2010
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Նմանատիպ նյութեր
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Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.
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Հրապարակվել է: (1994) -
Anti-CD3 antibody-induced suppression of collagen-induced arthritis in the DBA/1 mouse is associated with expansion of regulatory T cell subsets
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Հրապարակվել է: (2007) -
CD44 involvement in experimental collagen-induced arthritis (CIA).
: Nedvetzki, S, և այլն
Հրապարակվել է: (1999) -
Resistance to collagen-induced arthritis in DBA/1 mice by intraperitoneal administration of soluble type II collagen involves both CD4+ and CD8+ T lymphocytes.
: Williams, R, և այլն
Հրապարակվել է: (1989) -
Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.
: Williams, R, և այլն
Հրապարակվել է: (1995)