A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer

Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance...

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Үндсэн зохиолчид: Srinivasan, S, Kryza, T, Bock, N, Tse, BWC, Sokolowski, KA, Janaththani, P, Fernando, A, Moya, L, Stephens, C, Dong, Y, Röhl, J, Alinezhad, S, Vela, I, Perry-Keene, JL, Buzacott, K, Nica, R, Gago-Dominguez, M, Schleutker, J, Maier, C, Muir, K, Tangen, CM, Gronberg, H, Pashayan, N, Albanes, D, Travis, RC, Neal, DE
Формат: Journal article
Хэл сонгох:English
Хэвлэсэн: Nature Research 2024

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