TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.

TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.

Ligation of the TCR along with the coreceptor CD28 is necessary to elicit T cell activation in vivo, whereas TCR triggering alone does not allow a full T cell response. Upon T cell activation of human peripheral blood T cells, we found that the majority of cAMP was generated in T cell lipid rafts fo...

书目详细资料
Main Authors:	Abrahamsen, H, Baillie, G, Ngai, J, Vang, T, Nika, K, Ruppelt, A, Mustelin, T, Zaccolo, M, Houslay, M, Taskén, K
格式:	Journal article
语言:	English
出版:	2004

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