Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.

In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive irrefutable linkage and association results have been rare to date. Recently, it has been reported that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding Arg620Trp in...

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Bibliographic Details
Main Authors:	Smyth, D, Cooper, J, Collins, J, Heward, J, Franklyn, J, Howson, J, Vella, A, Nutland, S, Rance, H, Maier, L, Barratt, B, Guja, C, Ionescu-Tîrgoviste, C, Savage, D, Dunger, D, Widmer, B, Strachan, D, Ring, S, Walker, N, Clayton, D, Twells, R, Gough, S, Todd, J
Format:	Journal article
Language:	English
Published:	2004

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.

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