IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.

IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and...

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Bibliographic Details
Main Authors: Tzartos, J, Craner, M, Friese, M, Jakobsen, K, Newcombe, J, Esiri, M, Fugger, L
Format: Journal article
Language:English
Published: 2011