IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.
IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1797073639843037184 |
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| author | Tzartos, J Craner, M Friese, M Jakobsen, K Newcombe, J Esiri, M Fugger, L |
| author_facet | Tzartos, J Craner, M Friese, M Jakobsen, K Newcombe, J Esiri, M Fugger, L |
| author_sort | Tzartos, J |
| collection | OXFORD |
| description | IL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor-β). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21(+) infiltrating cells predominantly in acute but also in chronic active white matter MS lesions in which IL-21 expression was restricted to CD4(+) cells. In contrast, IL-21R was much more broadly distributed on CD4(+), CD19(+), and CD8(+) lymphocytes but not major histocompatibility complex class-II(+) macrophages/microglia. Interestingly, in cortical areas we detected both IL-21 and IL-21R expression by neurons. These findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons. |
| first_indexed | 2024-03-06T23:24:56Z |
| format | Journal article |
| id | oxford-uuid:6a07a81a-4eb9-431a-b469-f0efbb7ecd3e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:24:56Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:6a07a81a-4eb9-431a-b469-f0efbb7ecd3e2022-03-26T18:54:55ZIL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6a07a81a-4eb9-431a-b469-f0efbb7ecd3eEnglishSymplectic Elements at Oxford2011Tzartos, JCraner, MFriese, MJakobsen, KNewcombe, JEsiri, MFugger, LIL-17-producing CD4(+) T cells (Th-17) contribute to the pathogenesis of experimental autoimmune encephalomyelitis and are associated with active disease in multiple sclerosis (MS). In addition to IL-17, Th-17 cells can also express IL-21, IL-22, and IL-6 under Th-17-polarizing conditions (IL-6 and transforming growth factor-β). In this study we investigated IL-21 and IL-21 receptor (IL-21R) expression in MS lesions by in situ hybridization and immunohistochemistry. We detected strongly IL-21(+) infiltrating cells predominantly in acute but also in chronic active white matter MS lesions in which IL-21 expression was restricted to CD4(+) cells. In contrast, IL-21R was much more broadly distributed on CD4(+), CD19(+), and CD8(+) lymphocytes but not major histocompatibility complex class-II(+) macrophages/microglia. Interestingly, in cortical areas we detected both IL-21 and IL-21R expression by neurons. These findings suggest role(s) for IL-21 in both the acute and chronic stages of MS via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons. |
| spellingShingle | Tzartos, J Craner, M Friese, M Jakobsen, K Newcombe, J Esiri, M Fugger, L IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. |
| title | IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. |
| title_full | IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. |
| title_fullStr | IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. |
| title_full_unstemmed | IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. |
| title_short | IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. |
| title_sort | il 21 and il 21 receptor expression in lymphocytes and neurons in multiple sclerosis brain |
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