Mutational analysis of isoform selectivity and conformational equilibria in protein kinase inhibition
<p>Deregulation of protein kinases is associated with many diseases making them important targets for therapeutic intervention. Kinases can switch between active and inactive conformations that can be targeted by type 1 or type 2 inhibitors respectively. One of the most relevant conformational...
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| 格式: | Thesis |
| 语言: | English |
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2015
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