A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors

Thymic T-cell development is initiated from bone marrow-derived multi-potent thymus seeding progenitors (TSPs). During the early stages of thymocyte differentiation progenitors become T-cell restricted. However, the cellular environments supporting these critical initial stages of T-cell development...

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Bibliographic Details
Main Authors: Buono, M, Giustacchini, A, Mead, A, Jacobsen, S, Nerlov, C, Facchini, R, Matsuoka, S, Thongjuea, S, Luis, T, Besmer, P
Format: Journal article
Language:English
Published: Nature Publishing Group 2015